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DC Field | Value | Language |
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dc.contributor.author | Sharon R Mutenga | en_US |
dc.contributor.author | Bonolo B Phinius | en_US |
dc.contributor.author | Motswedi Anderson | en_US |
dc.contributor.author | Irene Gobe | en_US |
dc.contributor.author | Margaret Mokomane | en_US |
dc.contributor.author | Wonderful T Choga | en_US |
dc.contributor.author | Gorata Mpebe | en_US |
dc.contributor.author | Molly Pretorius-Holme | en_US |
dc.contributor.author | Rosemary Musonda | en_US |
dc.contributor.author | Tendani Gaolathe | en_US |
dc.contributor.author | Mompati Mmalane | en_US |
dc.contributor.author | Roger Shapiro | en_US |
dc.contributor.author | Joseph Makhema | en_US |
dc.contributor.author | Shahin Lockman | en_US |
dc.contributor.author | Vlad Novitsky | en_US |
dc.contributor.author | Max Essex | en_US |
dc.contributor.author | Sikhulile Moyo | en_US |
dc.contributor.author | Simani Gaseitsiwe | en_US |
dc.date.accessioned | 2023-05-22T07:22:03Z | - |
dc.date.available | 2023-05-22T07:22:03Z | - |
dc.date.issued | 2023-01-06 | - |
dc.identifier.uri | https://cris.library.msu.ac.zw//handle/11408/5653 | - |
dc.description.abstract | Background,We aimed to determine the prevalence of hepatitis B virus (HBV) infection among people with human immunodeficiency virus (PWH) in rural and periurban communities in Botswana.Methods.PWH from a previous population-based study, the Botswana Prevention Combination Project, which enrolled adults in 30 communities across Botswana (2013–2018), were screened for HBV surface antigen (HBsAg) and HBV core antibody (anti-HBc). HBsAg-positive (HBsAg+) samples were further screened for HBV core immunoglobulin M antibodies (anti-HBc immunoglobulin M [IgM]) and HBV e antigen (HBeAg). We quantified HBV viral load on participants who tested positive (n = 148) and negative for HBsAg (n = 381). Results.Of 3304 participants tested, 271 (8% [95% confidence interval {CI}, 7%–9%]) were HBsAg+ while 1788 (56% [95% CI, 54%–57%]) of 3218 PWH whom we tested had positive anti-HBc. Approximately 88% of HBsAg+ participants were on antiretroviral therapy (ART), 40% and 56% of whom were receiving lamivudine- and tenofovir-containing ART, respectively. Male sex (relative risk ratio [RRR], 1.8 [95% CI, 1.2–2.7]) and the northern geographic region (RRR, 2.5 [95% CI, 1.4–4.7]) were independent predictors of HBV infection (HBsAg+). Of 381 persons with negative HBsAg who were tested for occult HBV, 126 (33% [95% CI, 29%–38%]) had positive HBV DNA. Eleven participants were highly viremic with high HBV viral load while on a lamivudine- or tenofovir-containing regimen. Ten (91%) of these participants also had positive HBeAg serology, while 4 (36%) had positive anti-HBc IgM serology. Conclusions.The prevalence of HBV was high among PWH in Botswana while on ART regimens with activity against HBV. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | Open Forum Infectious Diseases | en_US |
dc.subject | Africa, | en_US |
dc.subject | Botswana | en_US |
dc.subject | hepatitis B virus | en_US |
dc.subject | human immunodeficiency virus | en_US |
dc.subject | occult HBV | en_US |
dc.title | High Prevalence of Hepatitis B Virus Infection Among People With HIV in Rural and Periurban Communities in Botswana | en_US |
dc.type | research article | en_US |
dc.identifier.doi | https://doi.org/10.1093/ofid/ofac707 | - |
dc.contributor.affiliation | Department of Applied Biological Sciences and Biotechnology, Faculty of Science and Technology, Midlands State University, Gweru, Zimbabwe. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.Department of Biological Sciences, Faculty of Sciences, University of Botswana, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.contributor.affiliation | Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA. | en_US |
dc.relation.issn | 2328-8957 | en_US |
dc.description.volume | 10 | en_US |
dc.description.issue | 1 | en_US |
dc.description.startpage | 1 | en_US |
dc.description.endpage | 15 | en_US |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairetype | research article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Research Papers |
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File | Description | Size | Format | |
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High Prevalence of Hepatitis B Virus Infection Among People Living with HIV in Rural and Peri-urban Communities in Botswana.pdf | Abstract | 67.03 kB | Adobe PDF | View/Open |
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